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Impact of cleaning and other interventions on the reduction of hospital-acquired C. diff infections assessed using a breakpoint model

“While multiple interventions are optimal to reduce the burden of CDI, it is believed that this study demonstrates that, in settings where cephalosporins are not widely used, effective cleaning and rapid isolation are the cornerstones of effective management and prevention of CDI, and have clearly been shown to work in practice.”

Hughes et al.

Health Protection Agency East of England, Institute of Public Health, Cambridge, UK Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK Peterborough & Stamford Hospitals NHS Foundation Trust, Peterborough City Hospital, Peterborough, UK Health Protection Agency, Public Health Laboratory, Cambridge, UK

Background

Hospital-acquired C.difficile is one of the biggest concerns in healthcare settings. Effective infection control interventions can be difficult to monitor.

Method

The infection control data from two hospitals in England was used for statistical breakpoint analysis.

Result

While a variety of interventions are needed to control C.diff, deep cleaning incorporating HPV decontamination is most effective in reducing CDI rates.

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